The desktop soft capsule machine is mainly used to pack round and round granular items in pharmaceutical, chemical and industrial products. Such as: sugar-coated tablets, plain tablets, steel balls, capsules and other materials packaging. It can continuously and automatically complete the whole process of bag making, measuring, filling, sealing, slitting, counting and other packaging, and is equipped with a photoelectric trademark positioning device, and can also add functions such as typing and incision.
The medicines made by the soft capsule machine process are:
1. Oily drugs and low melting point drugs are most suitable for making soft capsules. Oily drugs and drugs that are liquid or semi-solid at room temperature, in the past, for preparation, they were often treated by adsorption, curing and other technologies during preparation. Due to the addition of adsorbents and other auxiliary materials, the volume increased, or the preparation required heating and drying. At this time, the drug is easily freed or exuded from the adjuvant such as the adsorbent, which will cause the loss of the main drug and affect the curative effect. But soft capsule is to dissolve oily drug and low-melting drug with soluble solvent or make into emulsion for filling or dropping pills, eliminating the need for adsorption auxiliary materials, not only miniaturizing the preparation, but also avoiding the release and exudation of the drug Wait for the problem to appear. Such as Vitex oil capsules and indomethacin farnesoid capsules.
2. Drugs that are sensitive to light, unstable in the presence of humidity and heat, and easily oxidized can be made into soft capsules. Some drugs, such as volatile oils, are sensitive to light; some drugs are easily decomposed and volatilized when exposed to heat and humidity; some drugs are easily oxidized during preparation and storage. In order to prevent the drug from being decomposed by light, a light-shielding material such as titanium dioxide or iron oxide can be added to the capsule material for preparing the capsule, which will achieve good light stability. In order to prevent the medicine from contacting with air, inert gas can be introduced during the preparation process. The capsule material of soft capsule is composed of glycerin and gelatin, etc., with thick wall and no air permeability, so soft capsule is an excellent preparation for preventing drug oxidation. Such as E capsules, active D3 capsules and Luo calcium capsules.
3. Soft capsules can be made into rectal suppositories. The method is as follows: the main drug is dissolved or made into an oil-soluble suspension to prepare a soft capsule, and then the capsule is made into a suppository. Compared with the general suppository, the rectal capsule suppository is easier to diffuse and absorb in the rectum, and the preparation method is simpler than the general suppository, and the use is convenient. There are rectal capsules such as betamethasone and indomethacin that have been listed abroad.
4. It is a unique feature that medicines with bad odor and soft capsules of trace active medicines can cover up the bad odor of medicines. Some trace active drugs are in very small doses and are best made into soft capsules.
5. The drug soft capsule with volatile components and easy to escape can not only ensure the loss of volatile components in medicinal materials, but also avoid the loss of volatile oil after the preparation is placed, and improve the quality and efficacy of the drug.
6. Hydrophobic drugs with poor bioavailability can be made into microemulsions with oily carriers and then put into soft capsules, which can greatly improve their bioavailability. If other solid preparations are used, it is difficult for these drugs to achieve effective blood concentrations.