Soft capsule production technology and equipment
I. Overview
Soft capsules are a new dosage form developed after tablets and injections.
Quantitative injection of drug solution or drug suspension, paste and even drug powder and encapsulated in film
Inside, sealed capsules of different sizes and shapes are formed, which can be prepared by dropping method or pressing method. soft
The capsule material is made of gelatin, glycerin, plasticizers, preservatives, opacifiers, pigments and other suitable
Made of suitable medicinal materials. There are various sizes and shapes, including spherical (0.15 ~ 0.3ml),
Oval (0.10～0.5ml), rectangular (0.3～0.8ml) and cylindrical (0.4～4.5ml)
It can be made into different varieties for internal or external use according to clinical needs. The elasticity of the capsule shell is large,
Therefore, it is also called elastic capsule or capsule.
Main features of soft capsules:
1. Neat and beautiful, easy to swallow, and can cover up the unpleasant odor of drugs.
2. The filling volume is uniform and accurate, and the filling volume accuracy of the solution can reach ±1%, which is especially suitable for strong loading effect and excessive
Drugs with large side effects after the dose, such as steroid hormone oral contraceptives, etc.
3. The soft capsule is completely sealed, and its thickness can prevent oxygen from entering, so it is not suitable for volatile drugs or air
Drugs that are prone to spoilage can improve their stability and allow the drug to have a longer shelf life.
storage period.
4. It is suitable for low-melting solid medicines that are difficult to tablet or will be deformed during storage.
5, can improve the bioavailability of drugs.
6. It can be made into enteric-coated soft capsules and sustained-release preparations.
7. If it is an oily drug, technical treatment such as absorption and curing can also be omitted, which can effectively avoid
Oily drugs exude from the absorption excipients, so soft capsules are the most suitable formulations for oily drugs.
type.
8. In addition, low melting point drugs, hydrophobic drugs with poor bioavailability, unpleasant bitterness and
Odor-smelling drugs, trace active drugs, and those that are unstable and easily oxidized in the presence of light, humidity, heat
The drug is also suitable for soft capsules.
2. Main production equipment
Automatic seamless soft capsule machine
Manufacturer: Wuxi Jangli Machinery Co.,Ltd, this factory produces industrial chemicals
A series of soft capsule machines for production and laboratory use.
The soft capsule machine produced by our company comprehensively uses a variety of automatic control technologies, and the filling volume is precise.
Accurate, simple operation, compact structure, stable performance, reliable work, high output and low consumption, it adopts
The unique film adjustment mechanism reduces the cost of raw materials.
The main machine of the machine can be filled with liquid, ointment, tablet and powder, etc.
The filling accuracy of finished capsules can reach: liquid +2%, other +5%.
In addition, it is also equipped with conveyors, system control cabinets, roll molds, thermal insulation storage barrels, dry
Dryer etc.
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